Dry eye disease (DED) is a multifactorial chronic disease of the ocular surface characterized by a loss of homeostasis of the tear film, resulting in pain, visual impairment, tear film hyperosmolarity and instability, inflammation and corneal wounding. More than 340 million adults globally and approximately 34 million adults in the United States are estimated to suffer from DED
DED is characterized by a reduction in tear volume, rapid breakup of the tear film, and/or an increase in the evaporative properties of the tear film layer.
DED affects daily life, including reading and driving at night, and has been associated with depression and migraines. Despite the large prevalence of dry eye and the burden of the disease, there remains a significant unmet need for effective therapies.